Charles Fracchia & Joe Jacobson
Current tools for biological research are cumbersome and outdated. We are creating modern hardware and software tools that allow to draw insights from the experimental context.
Thrasyvoulos Karydis, Andreas Mershin & Joe Jacobson
We are working on prediction models for GPCR (G-protein coupled receptors) activation. Using olfactory receptors as a test case we are extracting information from primary sequence analysis, in order to pinpoint residues important for activation. Results are correlated with molecular dynamic simulations and in vitro experiments. GPCR activation is the major puzzle in drug discovery, where small molecules that activate only certain kinds of receptors are currently being found mostly by trial and error.
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