Manalis Laboratory - MIT Departments of Biological and Mechanical Engineering



J. Lee, R. Chunara, W. Shen, K. Payer, K. Babcock, T. P. Burg, S.R. Manalis. Suspended microchannel resonators with piezoresistive sensors, Lab on a chip (2010). Download PDF.

J. Lee, A.K. Bryan, S.R. Manalis. Second eigenmode operation of suspended microchannel resonators for high precision flow-through mass sensing, Review of Scientific Instruments (2010). Download PDF.

J.E. Sader, J. Lee, S.R. Manalis. Energy dissipation in microfluidic beam resonators: Dependence on mode number, Journal of Applied Physics (2010). Download PDF.

P. Dextras, K.R. Payer, T.P. Burg, W. Shen, Y.C. Wang, J. Han, S.R. Manalis. Fabrication and Characterization of an Integrated Microsystem for Protein Preconcentration and Sensing, IEEE Journal of Microelectromechanical Systems (2010). Download PDF.

J. Lee, W. Shen, K. Payer, T.P. Burg , S.R. Manalis. Toward attogram mass measurements in solution with suspended nanochannel resonators, Nano Letters (2010). Download PDF.

M. Godin, F.F. Delgado, S. Son, W.H. Grover, A.K. Bryan, A. Tzur, P. Jorgensen, K. Payer, A.D. Grossman, M.W. Kirschner, S.R. Manalis. Using buoyant mass to measure the growth of single cells, Nature Methods (2010). Download PDF. See also News & Views and highlight in Nature Biotechnology.

M.G. von Muhlen, N.D. Brault, S.M. Knudsen, S. Jiang, S.R. Manalis. Label-Free Biomarker Sensing in Undiluted Serum with Suspended Microchannel Resonators, Analytical Chemistry (2010). Download PDF.

J.E. Sader, T.P. Burg, S.R. Manalis. Energy Dissipation in Microfluidic Beam Resonators. Journal of Fluid Mechanics (2010). Download PDF.

A.K. Bryan, A. Goranov, A. Amon, S.R. Manalis. Measurement of Mass, Density, and Volume During the Cell Cycle of Yeast, Proceedings of the National Academy of Sciences (2009). Download PDF.

S.M. Knudsen, M. von Muhlen, D.B. Schauer, S.R. Manalis. Determination of Bacterial Antibiotic Resistance Based on Osmotic Shock Response. Analytical Chemistry (2009). Download PDF.

R. Datar, S. Kim, S. Jeon, P. Hesketh, S. Manalis, A. Boisen, T. Thundat. Cantilever Sensors: Nanomechanical Tools for Diagnostics. MRS Bulletin (2009). Download PDF.

T.P. Burg, J.E. Sader, S.R. Manalis. Nonmonotonic Energy Dissipation in Microfluidic Resonators. Physical Review Letters (2009). Download PDF.

P. Dextras, T.P. Burg, S.R. Manalis. Integrated Measurement of the Mass and Surface Charge of Discrete Microparticles Using a Suspended Microchannel Resonator. Analytical Chemistry (2009). Download PDF.

S. Son, W.H. Grover, T.P. Burg, S.R. Manalis. Suspended microchannel resonators for ultra-low volume universal detection. Analytical Chemistry (2008). Download PDF.

T.M. Squires, R.J. Messinger, S.R. Manalis. Making it stick: convection, reaction, and diffusion in surface based biosensors. Nature Biotechnology, 26 417 (2008). Download PDF. See also Suppl. Info.

W.H. Grover, M. von Muhlen, S.R. Manalis. Teflon films for chemically-inert microfluidic valves and pumps. Lab on a chip, 8 913 (2008). Download PDF.

R. Chunara, M. Godin, S. M. Knudsen, S.R. Manalis. Mass-based readout for agglutination assays. Applied Physics Letters, 91 193902 (2007). Download PDF.

M. Godin, A.K. Bryan, T. Burg, K. Babcock, S.R. Manalis. Measuring the mass, density and size of particles and cells using a suspended microchannel resonator. Applied Physics Letters, 91 123121 (2007). Download PDF.

T.P. Burg, M.Godin, S.M. Knudsen, W. Shen, G. Carlson, J.S. Foster, K. Babcock, and S.R. Manalis. Weighing of Biomolecules, Single Cells, and Single Nanoparticles in Fluid. Nature, 446 1066 (2007). Download PDF. See also News & Views.

J. Hou, M. Godin, K. Payer, R. Chakrabarti, S.R. Manalis. Integrated Microelectronic Device for Label-free Nucleic Acid Amplification and Detection. Lab on a Chip, 7 347 (2007). Download PDF.

N. Milovic, J. Behr, M. Godin, C.J. Hou, K.R. Payer, A. Chandrasekaran, P.R. Russo, R. Sasisekharan, S.R. Manalis. Monitoring of Heparin and Its Low Molecular Weight Analogs by Silicon Field Effect. Proceedings of the National Academy of Sciences, 103 13374 (2006). Download PDF.

M. Shusteff, T.P. Burg, S.R. Manalis. Measuring Boltzmann's constant with a low-cost atomic force microscope: an undergraduate experiment. American Journal of Physics, 74 873 (2006). Download PDF.

T.P. Burg, A.R. Mirza, N. Milovic, C.H. Tsau, G.A. Popescu, J.S. Foster, S.R. Manalis. Vacuum-Packaged Suspended Microchannel Resonant Mass Sensor for Biomolecular Detection. IEEE Journal of Microelectromechanical Systems, online (2006). Download PDF.

A.W. Sparks and S.R. Manalis. Atomic force microscopy with inherent disturbance suppression for nanostructure imaging. Nanotechnology, 17 1574 (2006). Download PDF.

C.J. Hou, N. Milovic, M. Godin, P.R. Russo, R. Chakrabarti, S.R. Manalis. Label-free Microelectronic PCR Quantification. Analytical Chemistry, 78 2526 (2006). Download PDF.

A.W. Sparks and S.R. Manalis. Scanning probe microcopy with inherent disturbance suppression. Applied Physics Letters, 85 3929 (2004). Download PDF.

C.A. Savran. S.M. Knudson, A.D. Ellington, S.R. Manalis. Micromechanical detection of proteins using aptamer-based receptor molecules. Analytical Chemistry, 76 3194 (2004). Download PDF.

T.P. Burg and S.R. Manalis. Suspended microchannel resonators for biomolecular detection. Applied Physics Letters, 83 2698 (2003). Download PDF.

C.A. Savran, T.P. Burg, J. Fritz, and S.R. Manalis. Microfabricated mechanical biosensor with inherently differential readout. Applied Physics Letters, 83 1659 (2003). Download PDF.

J. Fritz, E.B. Cooper, S. Gaudet, P.K. Sorger, and S.R. Manalis. Electronic detection of DNA by its intrinsic molecular charge. Proceedings of the National Academy of Sciences, 99 14142 (2002). Download PDF.

C.A. Savran, A.W. Sparks, J. Sihler, J. Li, W. Wu, D. Berlin, J. Fritz, M.A. Schmidt, and S.R. Manalis. Fabrication and characterization of a micromechanical sensor for differential detection of nanoscale motions. IEEE Journal of Microelectromechanical Systems, 11 703 (2002). Download PDF.

N.C. Loh, M.A. Schmidt, and S.R. Manalis. Sub-10 cm3 interferometric accelerometer with nano-g resolution. IEEE Journal of Microelectromechanical Systems, 11 182 (2002). Download PDF.

E. B. Cooper, J. Fritz, G. Wiegand, P. Wagner and S. R. Manalis. A robust microfabricated field-effect sensor for monitoring molecular adsorption in liquids. Applied Physics Letters, 79 3875 (2001). Download PDF.

Y.Gotoh, K. Matsumoto, T. Maeda, E. B. Cooper, S.R. Manalis, H. Fang, S.C. Minne, T. Hunt, H. Dai, J. Harris, C.F. Quate. Experimental and theoretical results of room-temperature single-electron transistor formed by the atomic force microscope nano-oxidation process. Journal of Vacuum Science Technology, 18 1321 (2000). Download PDF.

S.R. Manalis, E.B. Cooper, P.F. Indermuhle, P. Kernen, P. Wagner, D.G. Hafeman, S.C. H. Dai, S.C. Minne, C.F. Quate. Microvolume field-effect pH sensor for the scanning probe microscope. Applied Physics Letters, 76 1072 (2000). Download PDF.

E.B. Cooper, E.R. Post, S. Griffith, J. Levitan, S.R. Manalis, M.A. Schmidt, C.F. Quate. A high-sensitivity micromachined interferometric accelerometer. Applied Physics Letters, 76 3316 (2000). Download PDF.

E.B. Cooper, S.R. Manalis, H. Fang, H. Dai, K. Matsumoto, S.C. Minne, T. Hunt, C.F. Quate. Terabit-per-square-inch data storage with the atomic force microscope. Applied Physics Letters, 75 3566 (1999). Download PDF.