Enhancing human physical capability

Song, H., Herrera-Arcos, G., Friedman, G. N., Yeon, S. H., He, C., Gutierrez-Arango, S., Sinha, S., & Herr, H. M. (2025). A fatigue-resistant myoneural actuator for implantable biohybrid systems. bioRxiv. https://doi.org/10.1101/2025.03.14.642606

S. H. Yeon, C. Landis, G. Herrera-Arcos, H. Song and H. M. Herr, "Compact Reversible Nerve Block System for Wearable Bioelectronics," 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 2024, pp. 1-5, doi: 10.1109/EMBC53108.2024.10782179

Lee, D.R.C., Yang, X., Riccio-Ackerman, F. et al. A clinical comparison of a digital versus conventional design methodology for transtibial prosthetic interfaces. Sci Rep 14, 25833 (2024). https://doi.org/10.1038/s41598-024-74504-3

Rogers-Bradley, E., Yeon, S.H., Landis, C. et al. Variable-stiffness prosthesis improves biomechanics of walking across speeds compared to a passive device. Sci Rep 14, 16521 (2024). https://doi.org/10.1038/s41598-024-67230-3

Song, H., Hsieh, TH., Yeon, S.H. et al. Continuous neural control of a bionic limb restores biomimetic gait after amputation. Nat Med (2024). https://doi.org/10.1038/s41591-024-02994-9

Guillermo Herrera-Arcos et al. ,Closed-loop optogenetic neuromodulation enables high-fidelity fatigue-resistant muscle control. Science Robotics, 9, eadi8995 (2024). DOI: 10.1126/scirobotics.adi8995

Shu, T., Herrera-Arcos, G., Taylor, C.R. et al. Mechanoneural interfaces for bionic integration. Nat Rev Bioeng (2024). https://doi.org/10.1038/s44222-024-00151-y

Xingbang Yang, Ruoqi Zhao, Dana Solav, Xuan Yang, Duncan R.C. Lee, Bjorn Sparrman, Yubo Fan, Hugh Herr, Material, design, and fabrication of custom prosthetic liners for lower-extremity amputees: A review, Medicine in Novel Technology and Devices, Volume 17, 2023, 100197, ISSN 2590-0935, https://doi.org/10.1016/j.medntd.2022.100197

L. Chicos, D. Rangaprakash, R. Barry, H. Herr, Resting State Neurophysiology of Agonist-Antagonist Myoneural Interface in Persons with Transtibial Amputation. under review at Nature Communications Medicine. (2023).

Taylor CR, Yeon SH, Clark WH, Clarrissimeaux EG, O’Donnell MK, Roberts TJ and Herr HM (2022) Untethered muscle tracking using magnetomicrometry. Front. Bioeng. Biotechnol. 10:1010275. doi: 10.3389/fbioe.2022.1010275

Taylor CR, Clark WH, Clarrissimeaux EG, Yeon SH, Carty MJ, Lipsitz SR, Bronson RT, Roberts TJ and Herr HM (2022) Clinical viability of magnetic bead implants in muscle. Front. Bioeng. Biotechnol. 10:1010276. doi: 10.3389/fbioe.2022.1010276

Song H, Israel EA, Gutierrez-Arango S, Teng AC, Srinivasan SS, Freed LE, Herr HM. Agonist-antagonist Muscle Strain in the Residual Limb Preserves Motor Control and Perception after Amputation. Communication Medicine (Lond). 2022 Aug 5;2:97. doi: 0.1038/s43856-022-00162-z PMID35942078; PMC9356003 2022 (Publisher Correction 2022 Sep 26;2:121. doi: 10.1038/s43856-022-00188-3).

Yeon, Seong Ho, et al. "Acquisition of surface emg using flexible and low-profile electrodes for lower extremity neuroprosthetic control." IEEE Transactions on Medical Robotics and Bionics 3.3 (2021): 563-572.

Herr HM, Carty MJ. The Agonist-antagonist Myoneural Interface. Tech Orthop. 2021 Dec;36(4):337-344. doi: 10.1097/bto.0000000000000552. PMID: 34866774; PMCID: PMC8630671.

C. R. Taylor, S. S. Srinivasan, S. H. Yeon, M. K. O'Donnell, T. J. Roberts, H. M. Herr, Magnetomicrometry, Sci.Robot. 6, eabg0656 (2021), DOI: 10.1126/scirobotics.abg0656

Carty, M.J. and Herr, H.M. The Agonist-Antagonist Myoneural Interface. Hand Clinics. 2021 Aug;37(3):435-445. doi: 10.1016/j.hcl.2021.04.006. https://pubmed.ncbi.nlm.nih.gov/34253316/

Yeon SH, Shu T, Song H, Hsieh TH, Qiao J, Rogers EA, Gutierrez-Arango S, Israel E, Freed LE, Herr HM. Acquisition of Surface EMG Using Flexible and Low-Profile Electrodes for Lower Extremity Neuroprosthetic Control. IEEE Trans Med Robot Bionics. 2021 Aug;3(3):563-572. doi: 10.1109/TMRB.2021.3098952. PMID: 34738079; PMCID: PMC8562690.

M. E. Carney, T. Shu, R. Stolyarov, J. F. Duval and H. M. Herr, "Design and Preliminary Results of a Reaction Force Series Elastic Actuator for Bionic Knee and Ankle Prostheses," in IEEE Transactions on Medical Robotics and Bionics, vol. 3, no. 3, pp. 542-553, Aug. 2021, doi: 10.1109/TMRB.2021.3098921.

Srinivasan SS, Gutierrez-Arango S, Teng AC, Israel E, Song H, Bailey ZK, Carty MJ, Freed LE, Herr HM. Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2019555118. doi: 10.1073/pnas.2019555118

S. Srinivasan, S., M. Herr, H. A cutaneous mechanoneural interface for neuroprosthetic feedback. Nat Biomed Eng (2021). https://doi.org/10.1038/s41551-020-00669-7

S. S. Srinivasan, G. Tuckute, J. Zou., Guiterrez S., Seong H., Barry R., Herr H. “Agonist Antagonist Myoneural Interface Amputation Preserves Proprioceptive Sensorimotor Neurophysiology in Lower Limbs”, Science Translational Medicine (2020)

Yeon, Seong Ho, et al. "Flexible Dry Electrodes for EMG Acquisition within Lower Extremity Prosthetic Sockets." 2020 8th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob). IEEE.

E. A. Rogers, M. E. Carney, S. H. Yeon, T. R. Clites, D. Solav and H. M. Herr, "An Ankle-Foot Prosthesis for Rock Climbing Augmentation," in IEEE Transactions on Neural Systems and Rehabilitation Engineering, doi: 10.1109/TNSRE.2020.3033474.

M. E. Carney and H. Herr, "Electric-Energetic Consequences of Springs in Lower-Extremity Powered Prostheses on Varied Terrain," 2020 8th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), New York City, NY, USA, 2020, pp. 989-996, doi: 10.1109/BioRob49111.2020.9224458.

T.-H. Hsieh, “Design and Control of a Two-degree-of-freedom Powered Ankle-Foot Prosthesis”, Master’s thesis, Massachusetts Institute of Technology, 2019.

C. Taylor, Magnetomicrometry : Tissue length tracking via implanted magnetic beads (2020). https://dspace.mit.edu/handle/1721.1/130210

Carney, Matthew E. “Design and Evaluation of a Reaction-Force Series Elastic Actuator Configurable as Biomimetic Powered Ankle and Knee Prostheses By.” Massachusetts Institute of Technology, 2020.

C. R. Taylor, H. G. Abramson, and H. M. Herr, “Low-Latency Tracking of Multiple Permanent Magnets,” IEEE Sensors Journal, pp. 1–11, 2019.

S. Srinivasan, B. Schelhaas, B. E. Maimon, H. Song, H. M. Herr, Retinal supplementation augments optogenetic stimulation efficacy in vivo. J. Neural Eng. (2019)

T. R. Clites, M. J. Carty, S. S. Srinivasan, S. G. Talbot, R. Branemark, H. M. Herr, A caprine model of the agonist-antagonist myoneural interface as implemented at the above- and below-knee amputation levels.: Plastic and Reconstructive Surgery. 2019

S. Srinivasan, K. Vyas, M. McAvoy, P. Calvaresi, O. Khan, R. Langer, D. Anderson, H. Herr, Polyimide Electrode-based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration. Front. Neurol. 10 (2019),

S. S. Srinivasan, M. Diaz, M. Carty, H. M. Herr, Towards functional restoration for persons with limb amputation: A dual-stage implementation of regenerative agonist-antagonist myoneural interfaces. Sci. Rep. 9, 1981 (2019).

Solav, D., Moerman, K. M., Jaeger, A. M., & Herr, H. (2019). A framework for measuring the time-varying shape and full-field deformation of residual limbs using 3D digital image correlation. IEEE Transactions on Biomedical Engineering, 66(10), 2740-2752.

Shriya S. Srinivasan, Benjamin E. Maimon, Maurizio Diaz, Hyungeun Song and Hugh M. Herr, Nature Communications, volume 9, article number: 5303 (2018)

B. E. Maimon, K. Sparks, S. S. Srinivasan, A. N. Zorzos, H. M. Herr, Spectrally distinct channelrhodopsins for two-colour optogenetic peripheral nerve stimulation. Nature Biomedical Engineering 2, 485–496 (2018).

Solav, D., K. M. Moerman, A. M. Jaeger, K. Genovese, and H. M. Herr. MultiDIC: an Open-Source Toolbox for Multi-View 3D Digital Image Correlation. IEEE Access 6:30520–30535, 2018.

T. R. Clites, M. J. Carty, J. B. Ullauri, M. E. Carney, L. M. Mooney, J.-F. Duval, S. S. Srinivasan, H. M. Herr, Proprioception from a neurally controlled lower-extremity prosthesis. Sci. Transl. Med. 10, eaap8373 (2018).

M. Eilenberg, J. Kuan, and H. Herr. Development and Evaluation of a Powered Artificial Gastrocnemius for Transtibial Amputee Gait, Journal of Robotics, vol. 2018, Article ID 5951965, 15 pages, 2018.

Stolyarov, R. M., Burnett, G., & Herr, H. (2017). Translational Motion Tracking of Leg Joints for Enhanced Prediction of Walking Tasks. IEEE Transactions on Biomedical Engineering, 1-1. doi:10.1109/tbme.2017.2718528

S. S. Srinivasan, M. J. Carty, P. W. Calvaresi, T. R. Clites, B. E. Maimon, C. R. Taylor, A. N. Zorzos, H. Herr, On prosthetic control : A regenerative agonist-antagonist myoneural interface, 2, eaan2971 (2017).

T. R. Clites, M. J. Carty, H. M. Herr, in Plastic Surgery Research Council, (2017), p. 119.

T. R. Clites, M. J. Carty, S. Srinivasan, A. N. Zorzos, H. M. Herr, A murine model of a novel surgical architecture for proprioceptive muscle feedback and its potential application to control of advanced limb prostheses., J. Neural Eng. 14, aa614b (2017).

Clites TR, Carty MJ, Srinivasan S, Zorzos AN, Herr HM. J Neural Eng. 2017 EPub Feb 17;14(3):036002.

Maimon BE, Zorzos AN, Bendell R, Harding A, Fahmi M, Srinivasan S, Calvaresi P, Herr HM. J Neural Eng. 2017 Feb 3;14(3): 034002

Lin, B., Moerman, K. M., McMahan, C. G., Pasch, K. A., & Herr, H. M. Low-Cost Methodology for Skin Strain Measurement of a Flexed Biological Limb. IEEE Transactions on Biomedical Engineering, PP(99), 2016.

J.F. Duval, H. M. Herr

J.F. Duval, H. M. Herr

J. Markowitz and H. Herr. Human Leg Model Predicts Muscle Forces, States, and Energetics during Walking, PLoS Computational Biology, vol. 5, no. 12, May. 2016.

B. Maimon, A. N. Zorzos, K. W. Song, R. Bendell, R. Riso, H. M. Herr

Sengeh DM, Moerman, K. M., Petron A, Herr H.M.

H. M. Herr, T. R. Clites, B. Maimon, A. Zorzos, M. J. Carty, J.-F. Duval, Method And System For Providing Proprioceptive Feedback And Functionality Mitigating Limb Pathology. US Pending Patent 62/276422 (2016).

L. M. Mooney, H. M. Herr

H. M. Herr, R. R. Riso, K. W. Song, R. J.Casler, M. J. Carty, Peripheral Neural Interface Via Nerve Regeneration to Distal Tissues. US Patent US20160346099 (2016).

Moerman, K. M., Simms, C. K., Nagel, T. Control of tension-compression asymmetry in Ogden hyperelasticity with application to soft tissue modelling Journal of the Mechanical Behavior of Biomedical Materials, 56, 218–228, 2016

B.J. Ranger, M. Feigin, N. Pestrov, X. Zhang, V. Lempitsky, H.M. Herr, B.W. Anthony. “Motion compensation in a tomographic ultrasound imaging system: toward volumetric scans of a limb for prosthetic socket design”. Proceedings of the IEEE Engineering in Medicine and Biology Conference, 2015.

E. J. Rouse, N. C. Villagaray-Carski, R. W. Emerson, H. M. Herr

Duval, JF "FlexSEA: flexible, scalable electronics architecture for wearable robotic applications"