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New paper describes DNA sequencing procedure that provides a direct look at genomes

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Andrew Payne, Zack Chiang, Paul Reginato

Andrew Payne, Zack Chiang, Paul Reginato

by Sarah Beckmann

Jan. 5, 2021

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A new paper published in Science, "In situ genome sequencing resolves DNA sequence and structure in intact biological samples," describes work conducted by Edward Boyden and research assistants Andrew Payne and Paul Reginato from the Synthetic Neurobiology research group during their time at the Media Lab, prior to the group's move to MIT's McGovern Institute.

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Sequencing inside cells

A new approach to DNA sequencing gives researchers a direct view of genomes in their native environment
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New approach reveals genomes' sequence and structure directly within cells

In situ DNA sequencing method lets researchers study genomes in their native environment
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Andrew Payne Dissertation Defense

Scalable Methods for In Situ Genomics