Chatterjee, P., Ponnapati, M., Kramme, C. et al. Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Commun Biol 3, 715 (2020). https://doi.org/10.1038/s42003-020-01470-7

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Enzyme can target almost half of the genome’s “zipcodes” and could enable editing of many more disease-specific mutations