Living in space could have significant physical and mental impacts on astronauts. Wearables have the potential to play a critical role in monitoring, supporting, and sustaining human life in space, lessening the need for human medical expert intervention. Lab on Body is a device that integrates laboratory functions on a single integrated device to achieve customizable multiplex health monitoring automation. We demonstrated the vision of integrating such technology with the human body to sense biological signals related to health conditions at the molecular level. We have built prototypes of "wearable lab on body” that actively and continuously monitor human biomarkers from biological fluid. Our platform contains both digital sensors for contextual activity recognition, as well as an automated system for continuous sampling and sensing of chemical biomarkers from saliva by leveraging already existing paper-based biochemical sensors. This information collected from the body can be used to provide real-time feedback and assistance to the person in space, as well as to track their physical and mental health. The platform could aid with longitudinal studies of biomarkers and early diagnosis of diseases.