A major concern for manned missions is space radiation. Ionizing radiation is known to pose both acute and chronic risks to many organisms, including humans. At this time, it is important to expand strategies for radiation protection, including utilizing new materials and fabrication methods that can withstand different forms of radiation. The Mediated Matter group is researching the synthesis of biological pigments, including melanins and carotenoids, for biocompatible radioprotection. Such pigments can be fabricated for a variety of applications, creating a new class of materials and coatings that can protect life on Earth, in deep space, and beyond. Here, we examine the growth and behavior of five pigment-producing microorganisms after their placement in the interior of the International Space Station for one month as part of the RIDES payload. This experiment payload will launch on the SpaceX CRS-20 on March 6, 2020.