Shuguang Zhang

Research Affiliate

Groups

Publication

Structural bioinformatics studies of six human ABC transporters and their AlphaFold2- predicted water-soluble QTY variants

QRB Discov. 2024 Jan 19;5:e1. doi: 10.1017/qrd.2024.2. PMID: 38577032; PMCID: PMC10988169.

Publication

Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code

Li, M., Tang, H., Qing, R. et al. Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code. Nat Commun 15, 4293 (2024). https://doi.org/10.1038/s41467-024-48513-9

Publication

Study of glutamate transporters and their AF2 predicted water-soluble QTY variants and uncovering the natural mutations L->Q, I->T, F->Y,

Karago ̈l A, Karago ̈l T, Smorodina E, Zhang S (2024) Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F- >Y and Q->L, T->I and Y->F. PLoS ONE 19(4): e0289644.

Publication

Study of serotonin, dopamine, norepinephrine transporters and their AF2 predicted water-soluble QTY variants and uncovering natural mutation

Publication

Dynamic Dimerisation of Chemokine Receptors and Potential Inhibitory Role of Their Truncated Isoforms Revealed through Combinatorial Predict

Li, M.; Qing, R.; Tao, F.; Xu, P.; Zhang, S. Dynamic Dimerization of Chemokine Receptors and Potential Inhibitory Role of Their Truncated Isoforms Revealed through Combinatorial Prediction. Int. J. Mol. Sci.2023,24,16266. https:// doi.org/10.3390/ijms242216266

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QTY code designed antibodies for aggregation prevention: A structural bioinformatic and computational study

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CrMP‑Sol database: classification, bioinformatic analyses and comparison of cancer‑related membrane proteins and their water‑soluble variant

Publication

Structural bioinformatics studies of outer membrane beta-barrel transporters and their AlphaFold2 predicted water-soluble QTY variants

Publication

Making Sense of Helices: Right and Wrong Models in Science and Art

Martin Egli and Shuguang Zhang, Making Sense of Helices: Right and Wrong Models in Science and Art. MOLECULAR FRONTIERS JOURNAL l Volume 7 l 2023, 22 July 2023; doi:10.1142/S2529732523500086

Publication

Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays

Rui Qing, et al. "Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays." Science Advances. DOI: 10.1126/sciadv.adf1402

Publication

Structural informatics study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters

Structural informatics study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water‑soluble QTY variants

Publication

Protein Design: From the Aspect of Water Solubility and Stability

Chem. Rev. 2022, 122, 18, 14085–14179 https://doi.org/10.1021/acs.chemrev.1c00757

Publication

Hiding in plain sight: three chemically distinct α-helix types

Quarterly Reviews of Biophysics 55, e7, 1–10. https://doi.org/10.1017/S0033583522000063

Publication

Comparing 2 crystal structures and 12 AlphaFold2-predicted human membrane glucose transporters and their water-soluble glutamine, threonine

QRB Discovery, 3, E5. https://doi.org/10.1017/qrd.2022.6.pr1

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How the α-helix got its name

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Ned Seeman and the prediction of amino acid-base pair motifs mediating sequence-specific recognition of nucleic acid duplexes by proteins

Biophysical Journal 2022, S0006-3495(22)00476-3. doi: 10.1016/j.bpj.2022.06.017.

Publication

First prediction of sequence-specific recognition of double-helix nucleic acids by proteins

Nature Review Molecular Cell and Biology 23, 166 (2022).

Publication

Comparing Native Crystal Structures and AlphaFold2 Predicted Water-Soluble G Protein-Coupled Receptor QTY Variants

Michael A. Skuhersky, Fei Tao, Rui Qing, Eva Smorodina, David Jin, and Shuguang Zhang. "Comparing Native Crystal Structures and AlphaFold2 Predicted Water-Soluble G Protein-Coupled Receptor QTY Variants." Life 2021, 11, 1285. https://doi.org/10.3390/life11121285

Publication

Self-assembling peptide scaffolds in the clinic

Gelain, F., Luo, Z., Rioult, M. et al. Self-assembling peptide scaffolds in the clinic. npj Regen Med 6, 9 (2021). https://doi.org/10.1038/s41536-020-00116-w

Publication

Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Recepto

Publication

Self-assembling peptides: from a discovery in a yeast protein to diverse uses and beyond

Zhang, S. (2020) Self-assembling peptides: from a discovery in a yeast protein to diverse uses and beyond. Protein Science DOI:10.1002/pro.3951

Publication

QTY code-designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands.

Hao, SL., Jin D., Zhang, S. & Qing, R. (2020) QTY code-designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands. QRB Discovery 1 (e4) 1-9, Cambridge University Press

Publication

QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity

Rui Qing, Qiuyi Han, Michael Skuhersky, Haeyoon Chung, Myriam Badr, View ORCID ProfileThomas Schubert, and Shuguang Zhang. PNAS first published November 27, 2019 (https://doi.org/10.1073/pnas.1909026116). Edited by Alan R. Fersht, University of Cambridge, Cambridge, United Kingdom, and approved October 30, 2019 (received for review May 24, 2019).

Publication

Shuguang Zhang Publications List

For a full list of Shuguang Zhang's publications, please visit his website: https://www.moleculararchitecture.org/

Publication

QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities

Shuguang Zhang, Fei Tao, Rui Qing, Hongzhi Tang, Michael Skuhersky, Karolina Corin, Lotta Tegler, Asmamaw Wassie, Brook Wassie, Yongwon Kwon, Bernhard Suter, Clemens Entzian, Thomas Schubert, Ge Yang, Jörg Labahn, Jan Kubicek, Barbara Maertens. Proceedings of the National Academy of Sciences Sep 2018, 115 (37) E8652-E8659; DOI: 10.1073/pnas.1811031115

Publication

Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin...

Run Meng, Shilei Hao, Changfa Sun, Zongkun Hou, Yao Hou, Lili Wang, Peiying Deng, Jia Deng, Yaying Yang, Haijian Xia, Bochu Wang, Rui Qing, Shuguang Zhang. "Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice." PNAS.