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Project Research

Research Area | Application, Interpretability and Clinical Translation of Deep Learning Algorithms for Medical Images

Research studies led by Dr. Shah in his laboratory have created new paradigms for using low-cost images captured using simple optical …
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Archived
Project Research

Research Area | Emergent Neural Networks to Redesign Clinical Testing of Medicines and Learning from Real World Evidence

Research studies led by Dr. Shah, in collaboration with the United States Food and Drug Administration (FDA),  have develope…
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Archived
Project Research

Research Area | Rapid Fabrication and Integration of Medical Devices and Technologies

Dr. Shah and his research lab at MIT has significant expertise and motivation to bring problems from the clinic and society into the labora…
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Archived
Project Research

Toolkit for real-world performance evaluation of medical grade deep learning models

MotivationResearch studies from Dr. Shah's lab have described several deep learning methods and models to assist clinical decision-making u…
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Archived
Project Research

On-site Analysis of Foodborne Pathogens Using Density-Shift Immunomagnetic Separation and Culture

Foodborne pathogens are a major source of human morbidity, food recalls, and economic loss. Current detection methods for foodborne pathoge…
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Archived
Project Research

Deep Learning to Develop and Analyze Computational Hematoxylin and Eosin Staining of Tissue Images for Digital Biopsies

Staining of tissues sections using chemical and biological dyes has been used for over a century for visualizing various tissue types and m…
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Archived
Project Research

Self-Learning AI Model Learns from Patient Data to Design Novel Clinical Trials

Technical summaryUnstructured learning problems without well-defined rewards are unsuitable for current reinforcement learning (RL) approac…
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Archived
Project Research

Digital Clinical Trials with Novel Machine Learning and AI Architectures

Dr. Shah was an invited speaker and a contributor at The National Cancer Policy Forum developed workshop series at the The National Academi…
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Archived
Project Research

AI Methods for Rapid Automated Staining and Destaining of Tissue Biopsies in Hospitals

General OverviewStaining of tissues sections using chemical and biological dyes has been used for over a century for visualizing various ti…
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Archived
Project Research

Helping Emergency Care Physicians Diagnose Sepsis and Bacterial Infections with Machine Learning and Vision

General overview:Sepsis, a life-threatening complication of bacterial infection, leads to millions of worldwide deaths requires significant…
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Archived
Project Research

Artificial Intelligence and Machine Learning in Clinical Development: A Translational Perspective

Technical summary: Future of clinical development is on the verge of a major transformation due to convergence of large new digital data so…
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Archived
Project Research

Technology-Enabled Mobile Phone Screenings Augment Routine Primary Care

We have developed a new process to screen patients at the point-of-care with FDA-approved technology-enabled mobile health screenings (TES)…
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Project Research

Machine Learning for Combined Classification of Fluorescent Biomarkers and Expert Annotations Using White Light Images

Biomarker imaging provides non-invasive indicators of disease and is used by human experts to augment disease diagnosis. It is, however, of…
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Project Research

Machine Learning from Biomarker Signatures and Correlation to Systemic Health Conditions

Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated…
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Project Research

Machine Learning and Automated Segmentation of Oral Diseases Using Biomarker Images

We report a novel method that processes biomarker images collected at the point of care and uses machine learning algorithms to provide a f…
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Archived
Project Research

Detecting Biomarkers with Printable Paper Diagnostics

Paper diagnostics can be used for affordable and scalable biomarker detection. We propose new methods for stabilizing cellulose-based immun…
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Archived
Project Research

At-Home Sleep Apnea Screening

A large proportion of the American population currently suffers from sleep disorders. Among them are patients with obstructive sleep apnea …
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Archived
Project Research

Non-Ionizing Imaging for Medical Diagnosis Instead of 2D Radiography and Cone-Beam Computed Tomography

Two-dimensional radiographs are commonly used for evaluating sub-surface hard structures of teeth, but they have low sensitivity for early …
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Project Research

Near-Infrared Transillumination Guides Administration of Dental 2D Radiography and Cone Beam Computed Tomography Imaging

Two-dimensional radiographs are commonly used for evaluating sub-surface hard structures of teeth, but they have low sensitivity for early …
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Archived
Project Research

Near-Infrared Imaging for Detecting Dental Caries

Two-dimensional radiographs are commonly used for evaluating sub-surface hard structures of teeth, but they have low sensitivity for early …
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Archived
Project Research

Biomarker Imaging with Mobile Phones

We built a low-cost and open source 405 nm imaging device to capture red fluorescence signatures associated with the oral biomarker porphyr…
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