Engineering at the limits of complexity with molecular-scale parts

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Attribution 4.0 International

Soumya Tripathy

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Project Research

How to Grow (Almost) Anything - A New Model for Global Synthetic Biology Education

A Distance Learning Model for Global Laboratory-Based Synthetic Biology Education Synthetic Biology ( SynBio) tools hold the…
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Non-full-length G protein-coupled receptors: An unexpected discovery may lead to design new molecular devices

It was believed that functionalities of G protein-coupled receptors (GPCRs) require full-length sequences which are negated by residue dele…
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Scaling Science: Using Data to Find “Hidden Gem” Research

The current system of scientific recognition and funding has significant bias towards work published in the top few percent of journal…
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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has elicited a global health crisis of catastrophic proportions. With on…
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Robust Genome Editing with Broad Targeting CRISPR Enzymes

Programmable CRISPR enzymes are powerful and versatile tools for genome editing. They, however, require a specific protospacer adjacent mot…
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Designer molecular mops: Water-soluble cytokine receptors fused with Fc domain of IgG may be therapeutic for cytokine storms

In April 2019, Shuguang Zhang's lab started to use the QTY code to design a class of water-soluble cytokine receptors, including interferon…
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QTY code designs for water-soluble beta-barrel transmembrane proteins

In collaboration with Prof. Tao Fei’s lab (Shanghai Jiaotong University, China)In addition to a large number of membrane proteins that comp…
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The QTY code: A simple tool for protein design

Structure and function studies of membrane proteins, particularly G protein-coupled receptors (GPCRs) and multipass transmembrane proteins,…
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QTY CXCR4 becomes more hydrophilic and retains cell signaling activity

In collaboration with Prof. Horst Vogel and Dr. Horst Pick (EPFL, Lausanne, Switzerland).G protein-coupled receptors (GPCRs) are vital for …
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Membrane receptor-based high molecular density bioelectronic platform

In collaboration with Prof. Uwe Sleytr and Dr. Andreas Breitwieser (BOKU, Vienna, Austria).Bioelectronics is an emerging antidisciplinary f…
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Water-soluble transmembrane protein receptors with exchangeable and tunable ligand affinity

There are 20 chemokine receptors that bind their respective chemokines. It is not currently understood how these structurally similar recep…
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DeepPPI

Protein-protein interactions (PPIs) are an essential part of many biological pathways in living organisms. With use cases such as regulatio…
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Opening wider genomic access with a flexible CRISPR enzyme

The CRISPR-Cas9 system has proven to be a versatile tool for genome editing, with numerous implications in medicine, agriculture, bioe…
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Affinity: Deep Learning API for Molecular Geometry

Affinity is a high-level machine learning API (Application Programming Interface) dedicated exclusively to molecular geometry. Affinity is …
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Synthetic Genome Engineering

We are currently developing novel DNA editing technologies to broaden the scope of genome engineering. Our strategy is based on identifying…
Project Research

Evolutron: Deep Learning for Protein Design

Technological advances in the past decade have allowed us to take a close look at the proteomes of living organisms. As a result, more than…