Engineering at the limits of complexity with molecular-scale parts

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Molecular Machines group

Molecular Machines group

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Project Research

Non-full-length G protein-coupled receptors: An unexpected discovery may lead to design new molecular devices

It was believed that functionalities of G protein-coupled receptors (GPCRs) require full-length sequences which are negated by residue de...
Project Research

Scaling Science: Using Data to Find “Hidden Gem” Research

The current system of scientific recognition and funding has significant bias towards work published in the top few percent of journ...
Project Research

Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has elicited a global health crisis of catastrophic proportions. With ...
Project Research

Robust Genome Editing with Broad Targeting CRISPR Enzymes

Programmable CRISPR enzymes are powerful and versatile tools for genome editing. They, however, require a specific protospacer adjacent m...
Project Research

Designer molecular mops: Water-soluble cytokine receptors fused with Fc domain of IgG may be therapeutic for cytokine storms

In April 2019, Shuguang Zhang's lab started to use the QTY code to design a class of water-soluble cytokine receptors, including interfer...
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QTY code designs for water-soluble beta-barrel transmembrane proteins

In collaboration with Prof. Tao Fei’s lab (Shanghai Jiaotong University, China)In addition to a large number of membrane proteins that co...
Project Research

The QTY code: A simple tool for protein design

Structure and function studies of membrane proteins, particularly G protein-coupled receptors (GPCRs) and multipass transmembrane protein...
Project Research

QTY CXCR4 becomes more hydrophilic and retains cell signaling activity

In collaboration with Prof. Horst Vogel and Dr. Horst Pick (EPFL, Lausanne, Switzerland).G protein-coupled receptors (GPCRs) are vital fo...
Project Research

Membrane receptor-based high molecular density bioelectronic platform

In collaboration with Prof. Uwe Sleytr and Dr. Andreas Breitwieser (BOKU, Vienna, Austria).Bioelectronics is an emerging antidisciplinary...
Project Research

Water-soluble transmembrane protein receptors with exchangeable and tunable ligand affinity

There are 20 chemokine receptors that bind their respective chemokines. It is not currently understood how these structurally similar rec...
Project Research

DeepPPI

Protein-protein interactions (PPIs) are an essential part of many biological pathways in living organisms. With use cases such as regulat...
Project Research

Opening wider genomic access with a flexible CRISPR enzyme

The CRISPR-Cas9 system has proven to be a versatile tool for genome editing, with numerous implications in medicine, agriculture, bi...
Project Research

Affinity: Deep Learning API for Molecular Geometry

Affinity is a high-level machine learning API (Application Programming Interface) dedicated exclusively to molecular geometry. Affinity i...
Project Research

Synthetic Genome Engineering

We are currently developing novel DNA editing technologies to broaden the scope of genome engineering. Our strategy is based on identifyi...
Project Research

Evolutron: Deep Learning for Protein Design

Technological advances in the past decade have allowed us to take a close look at the proteomes of living organisms. As a result, more th...