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High-resolution imaging with conventional microscopes:Tissue-expansion technique could allow scientists to map brain circuits.
Brain circuits are large, 3D structures. However, the building blocks—proteins, signaling complexes, synapses—are or...
Revealing insights into the human condition and repairing brain disorders via novel tools for mapping and fixing brain computations
In order to map the dynamics of neural circuits in mammalian brains, we need tools that can record activity over large volumes of tissue ...
We are providing our tools to the community, and also using them within our lab, to analyze how specific brain mechanisms (molecular, cel...
The brain is a three-dimensional, densely-wired circuit that computes via large sets of widely distributed neurons i...
We have pioneered the development of fully genetically encoded reagents that, when targeted to specific cells, enabl...
We have developed a set of "optogenetic" reagents: fully genetically encoded reagents that, when targeted to specifi...
New technologies for recording neural activity, controlling neural activity, or building brain circuits, may be capable some day of servi...