Research
Mediated Matter

Designing for, with, and by nature
Research
Tangible Media

Seamlessly coupling the worlds of bits and atoms by giving dynamic physical form to digital information and computation
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Sculpting Evolution

Cultivating wisdom through evolutionary and ecological engineering
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Space Exploration Initiative

Space Exploration Initiative
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Health 0.0

Health 0.0
Research
Beyond the Cradle

Beyond the Cradle
Project Research

Totems

Biodiversity on planet Earth is under momentous threat, with extinction rates estimated between 100 and 1,000 times their pre-human level...
Project Research

Aguahoja

Programmable Water-Based Biocomposites for Digital Design and Fabrication across ScalesAguahoja is an exploration of nature’s design spac...
Project Research

Tools for mapping the molecular architecture and wiring of the brain

Complex biological systems such as brain circuits are extended 3-D structures made out of nanoscale building blocks such as proteins, RNA...
Research
Biomechatronics

Enhancing human physical capability
Archived
Research
Design Fiction

Sparking discussion about the social, cultural, and ethical implications of emerging technologies through design and storytelling
Research
Fluid Interfaces

Designing systems for cognitive enhancement
Project Research

Theme | Wearable Biotech Enhancement

Lab on Body, Synthetic Biology, and Bio-Digital Systems for Health and Human Enhancement
Research
Nano-Cybernetic Biotrek

Inventing disruptive technologies for nanoelectronic devices and creating new paradigms for life-machine symbiosis
Project Research

Mice Against Ticks - Preventing tick-borne disease by permanently immunizing mice

Lyme disease is the most common vector-borne infection in North America. People are infected when bitten by ticks; ticks are typically in...
Research
Molecular Machines

Engineering at the limits of complexity with molecular-scale parts
Research
Community Biotechnology

Community Biotechnology
Archived
Research
Collective Learning

Transforming data into knowledge
Project Research

Research Area | Novel Ethical, Secure and Explainable Artificial Intelligence based Digital Medicines and Treatments

We have described validation of novel machine learning architectures for designing faster, safer, and more efficacious digital medicines ...
Project Research

Digital Clinical Trials with Novel Machine Learning and AI Architectures

Dr. Shah was an invited speaker and a contributor at The National Cancer Policy Forum developed workshop series at the The National Acade...
Article Research

Neri Oxman has all the answers

Mediated Matter head Neri Oxman talks to ELLE about her work.
Project Research

Gemini

Gemini—an acoustical “twin chaise"—spans multiple scales of the human existence extending from the warmth of the womb to the stretches ...
Project Research

Water-Based Additive Manufacturing

This research presents water-based robotic fabrication as a design approach and enabling technology for additive manufacturing (AM) of bi...
Research
Center for Extreme Bionics

Center for Extreme Bionics
Project Research

Evolutron: Deep Learning for Protein Design

Technological advances in the past decade have allowed us to take a close look at the proteomes of living organisms. As a result, more th...
Project Research

Tools for recording high-speed brain dynamics

The brain is a three-dimensional, densely-wired circuit that computes via large sets of widely distributed neurons interacting at fast ti...
Project Research

Prototype strategies for treating brain disorders

New technologies for recording neural activity, controlling neural activity, or building brain circuits, may be capable someday of servin...
Project Research

Daisy Drives

Who should decide whether, when, and how to alter the environment? These are hard questions, especially when the decisions will impact pe...
Article Research

Keeping genetic engineering localized

In a paper published in PNAS, researchers at MIT and Harvard University describe a self-limiting gene drive system.
Research
Synthetic Neurobiology

Revealing insights into the human condition and repairing brain disorders via novel tools for mapping and fixing brain computations
Project Research

Silk Pavilion

The Silk Pavilion explores the relationship between digital and biological fabrication on product and architectural scales.The primary ...
Article Research

Fake meat, served six ways

We now have more challenging choices to make than simply whether to be vegan, pescatarian or carnivore, thanks to technology.
Project Research

Brainstorm: Anima Mundi

We'd like to introduce you to a very special neuroscience project that we are currently conducting in the setting of a traditional fine a...
Article Research

When Are We Obligated To Edit Wild Creatures?

Given the power to alter the workings of the natural world, are we morally obligated to use it?
Publication Research

Current CRISPR gene drive systems are likely to be highly invasive in wild populations

eLife 2018;7:e33423 DOI: 10.7554/eLife.33423
Article Research

I'm Kevin Esvelt, head of the Sculpting Evolution group at the MIT Media Lab and an inventor of CRISPR gene drive - AMA!

I'm a strong advocate of more open science, and my group tries to carefully consider our moral obligations and publicly admit mistakes.
Article Research

Gene Editing: Last Week Tonight with John Oliver

Scientists are developing new ways to alter the genetic code of living organisms. John Oliver explores the risks and rewards.
Article Research

The public doesn’t trust GMOs. Will it trust CRISPR?

There’s a huge opportunity to improve agriculture with gene editing. But we need to give CRISPR a chance.
Article Research

Neri Oxman and MIT develop digitally produced water-based renewable material

Neri Oxman and a group of researchers from the MIT Mediated Matter group have developed a water-based digital fabrication platform.
Article Research

Can we make life?

A revolution in gene editing enables scientists to create and edit DNA like never before.
Post Research

Aotearoa: Mistakes and Amends

Researchers should hold themselves morally accountable for all of the consequences of their work. That can require publicly acknowledging...
Article Research

Archon: A fluorescent voltage indicator for imaging neural activity

Fluorescent sensor allows imaging of neurons' electrical communications, without electrodes
Article Research

A neurobiologist thinks big — and small

Ed Boyden advances on his goal of understanding how the brain works.
Article Research

Biotech breakthroughs and big ideas in 2018

Innovations are looming in food, medicine, brain-machine interfaces, sex, sleep, and do-it-yourself biology. That’s the picture we got fr...
Publication Research

Chimeric CRISPR guides enhance Cas9 target specificity

Noah Jakimo, Pranam Chatterjee, Joseph M. Jacobson. Chimeric CRISPR guides enhance Cas9 target specificity, doi: https://doi.org/10.1101/147686
Article Research

Making the body sing

A strange song, full of pumping percussion and instrumentals with random patterns, began to erupt from the speakers.David Sun Kong ’...
Article Research

Live from HUBweek 2017

Julie Kramer interviewed several participants at HUBweek 2017, including Community Biotechnology head David Sun Kong.
Article Research

MIT researchers propose release of genetically engineered mice on Nantucket

NANTUCKET, Mass. -- On the picturesque island of Nantucket, residents are considering a radical approach to fight a disease that's haunte...
Archived
Project Research

Open Source Estrogen

Biomolecules to biopolitics: hormones with institutional biopower! Open Source Estrogen combines do-it-yourself science, body and gender ...
Archived
Project Research

Synthetic Genome Engineering

We are currently developing novel DNA editing technologies to broaden the scope of genome engineering. Our strategy is based on identifyi...
Project Research

Responsive Science

Responsive Science is a way of conducting research that invites openness and community involvement from the earliest stages of each proje...
Article Research

David Kong at SB7.0

David Kong at the 7th International Meeting on Synthetic Biology
Post Research

Expansion Pathology

Enlarging clinical samples for imaging to understand the building blocks of pathologies with nanoscale precision
Publication Research

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Grossman N, Bono D, Dedic N*, Kodandaramaiah SB*, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES (2017) Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell 169(6):1029-1041. (* equal contribution)
Publication Research

Optogenetics: Tools for Controlling and Monitoring Neuronal Activity

T. Knopfel and E. Boyden, eds. (2012) Optogenetics: Tools for Controlling and Monitoring Neuronal Activity, Progress in Brain Research, vol. 196, Elsevier.
Post Research

A noninvasive method for deep brain stimulation

Electrodes placed on the scalp could help patients with brain diseases.
Article Research

New electrical brain stimulation technique shows promise in mice

A team of neuroscientists and engineers has devised a method that might achieve the best of both worlds: skipping the surgery while reachin